Splenectomy Is Modifying the Vascular Remodeling of Thrombosis
نویسندگان
چکیده
منابع مشابه
Splenectomy Is Modifying the Vascular Remodeling of Thrombosis
BACKGROUND Splenectomy is a clinical risk factor for complicated thrombosis. We hypothesized that the loss of the mechanical filtering function of the spleen may enrich for thrombogenic phospholipids in the circulation, thereby affecting the vascular remodeling of thrombosis. METHODS AND RESULTS We investigated the effects of splenectomy both in chronic thromboembolic pulmonary hypertension (...
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Chronic increases in arterial blood flow elicit an adaptive response of the arterial wall, leading to vessel enlargement and reduction in wall shear stress to physiological baseline value. Release of nitric oxide from endothelial cells exposed to excessive shear is a fundamental step in the remodeling process, and potentially triggers a cascade of events, including growth factor induction and m...
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این مقاله فاقد چکیده میباشد.
متن کاملPortal Vein Thrombosis after Splenectomy
Background and Aim of the work: Splenectomy is a common operation but it carries the danger of many postoperative complications. One of the most important complications is the portal vein thrombosis (PVT), which may be fatal due to development of bowel ischemia and severe portal hypertension. Due to the effect of hypobaric hypoxia and higher liability for thrombosis encountered in high altitude...
متن کاملStrain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined.
BACKGROUND Atherosclerosis of the carotid artery, called intima-media thickening (IMT), is a form of vascular remodeling that is an important predictor for cardiovascular events and has a strong genetic component. METHODS AND RESULTS Recently, we established a mouse model of vascular remodeling based on partial ligation of the carotid, which is relevant to the "Glagov phenomenon." We hypothes...
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ژورنال
عنوان ژورنال: Journal of the American Heart Association
سال: 2014
ISSN: 2047-9980,2047-9980
DOI: 10.1161/jaha.113.000772